| 货号 | 81035-10mg |
| 描述 | CDDO is a synthetic oleanane triterpenoid that blocks the cellular synthesis of inducible nitric oxide synthase and inducible COX-2 in INF-γ-activated mouse macrophages with an IC50 value of 0.4 nM.1 By suppressing reactive oxygen and nitrogen species (ROS/RNS) formation, it promotes the cellular control of ROS/RNS levels that would lead to DNA damage associated with tumorigenesis.2 In various cancer cell lines, CDDO has been shown to specifically inhibit proliferation and induce apoptosis.2 Mechanism studies revealed that CDDO is a ligand for peroxisome proliferator-activated receptor γ, and also that it induces genes regulated by Nrf2, including heme oxygenase-1 and eotaxin-1, which play a role in antioxidant response element signaling activity.3,4,5 |
| 别名 | Bardoxolone;RTA 401; |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Honda, T.,Rounds, B.V.,Gribble, G.W., et al. Design and synthesis of 2-cyano-3,12-dioxoolean-1,9-dien-28-oic acid, a novel and highly active inhibitor of nitric oxide production in mouse macrophages. Bioorganic & Medicinal Chemistry Letters 8, 2711-2714 (1998). 2.Suh, N.,Wang, Y.,Honda, T., et al. A novel synthetic oleanane triterpenoid, 2-cyano-3,12-dioxoolean-1,9-dien-28-oic acid, with potent differentiating, antiproliferative, and anti-inflammatory activity. Cancer Research 59, 336-341 (1999). 3.Ferguson, H.E.,Kulkarni, A.,Lehmann, G.M., et al. Electrophilic peroxisome proliferator-activated receptor-γ ligands have potent antifibrotic effects in human lung fibroblasts. American Journal of Respiration, Cell, and Molecular Biology 41, 722-730 (2009). 4.Liby, K.,Hock, T.,Yore, M.M., et al. The synthetic triterpenoids, CDDO and CDDO-imidazolide, are potent inducers of heme oxygenase-1 and Nrf2/ARE signaling. Cancer Research 65, 4789-4798 (2005). 5.Fourtounis, J.,Wang, I.M.,Mathieu, M.C., et al. Gene expression profiling following NRF2 and KEAP1 siRNA knockdown in human lung fibroblasts identifies CCL11/Eotaxin-1 as a novel NRF2 regulated gene. Respiratory Research 13(1), (2012). | |
| 运输条件 | Wet ice in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥95% |
| 计算分子量 | 491.7 |
| 分子式 | C31H41NO4 |
| CAS号 | 218600-44-3 |
| 稳定性 | ≥ 2 years |
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