| 货号 | 75500-50mg |
| 描述 | Serum amyloid P (SAP) is pentraxin with roles in inflammation and immune response.1,2 CPHPC is a divalent crosslinker of SAP that causes rapid depletion of circulating SAP via hepatic clearance.3 It also produces significant reduction of SAP from cerebrospinal fluid and visceral amyloid deposits.3,4,5 CPHPC has been used with anti-SAP antibodies to eliminate amyloid deposits in clinical trials of systemic amyloidosis.5,6 |
| 别名 | Ro 63-8695;GSK2315698; |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Du Clos, T.W. Pentraxins: Structure, function, and role in inflammation. ISRN Inflamm. 2013, (2013). 2.Cox, N.,Pilling, D., and Gomer, R.H. Serum amyloid P: A systemic regulator of the innate immune response. Journal of Leukocyte Biology 96(5), 739-743 (2014). 3.Pepys, M.B.,Herbert, J.,Hutchinson, W.L., et al. Targeted pharmacological depletion of serum amyloid P component for treatment of human amyloidosis. Nature 417, 254-259 (2002). 4.Kolstoe, S.E.,Ridha, B.H.,Bellotti, V., et al. Molecular dissection of Alzheimer’s disease neuropathology by depletion of serum amyloid P component. Proceedings of the National Academy of Sciences of the United States of America 106(18), 7619-7623 (2009). 5.Bodin, K.,Ellmerich, S.,Kahan, M.C., et al. Antibodies to human serum amyloid P component eliminate visceral amyloid deposits. Nature 468, 93-97 (2010). 6.Sahota, T.,Berges, A.,Barton, S., et al. Target mediated drug disposition model of CPHPC in patients with systemic amyloidosis. CPT Pharmacometrics Syst.Pharmacol. 4(2), 116-126 (2015). | |
| 运输条件 | Wet ice in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥95% |
| 计算分子量 | 340.4 |
| 分子式 | C16H24N2O6 |
| CAS号 | 224624-80-0 |
| 稳定性 | ≥ 2 years |
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