NFAT Activation Inhibitor III
货号：
21812-50mg 基本售价：
5488.0 元 规格：
50 mg
产品信息
概述| 货号 | 21812-50mg |
| 描述 | NFAT activation anhibitor III is a cell-permeant inhibitor of signaling through nuclear factor of activated T cells (NFAT).1 It binds the substrate recognition site of the phosphatase calcineurin (Kd = 0.8 µM), preventing it from binding and dephosphorylating NFAT.1 NFAT activation inhibitor III blocks the nuclear import of NFAT in T cells stimulated with ionomycin (Item No. 10004974). It prevents the induced expression of cytokine mRNAs in T cells stimulated with phorbol ester and ionomycin.1 |
| 别名 | INCA-6;NSC 25996; |
性能| 供应商 | Cayman |
| 应用文献 |
1.Roehrl, M.H.A.,Kang, S.,Aramburu, J., et al. Selective inhibition of calcineurin-NFAT signaling by blocking protein-protein interaction with small organic molecules. Proceedings of the National Academy of Sciences of the United States of America 101(20), 7554-7559 (2004).
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| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 284.3 |
| 分子式 | C20H12O2 |
| CAS号 | 3519-82-2 |
| 稳定性 | ≥ 2 years |
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