Chlorcyclizine (hydrochloride)
货号：
19239-1g 基本售价：
5488.0 元 规格：
1 g
产品信息
概述| 货号 | 19239-1g |
| 描述 | Chlorcyclizine is a phenylpiperazine that acts as a histamine H1 receptor antagonist (Ki = 9 nM).1 It has also been shown to be effective against hepatitis C virus (HCV; EC50 = 44 nM in vitro), preventing viral entry into host cells.2 In chimeric mice engrafted with primary human hepatocytes, 10-50 mg/kg chlorcyclizine significantly inhibited infection of HCV genotypes 1b and 2a.2 |
| 别名 | NSC 169496; |
性能| 供应商 | Cayman |
| 应用文献 |
1.Tran, V.T.,Chang, R.S.L., and Snyder, S.H. Histamine H1 receptors identified in mammalian brain membranes with [3H]mepyramine. Proceedings of the National Academy of Sciences of the United States of America 75(12), 6290-6294 (1978).
2.He, S.,Xiao, J.,Dulcey, A.E., et al. Discovery, optimization, and characterization of novel chlorcyclizine derivatives for the treatment of hepatitis C virus infection. Journal of Medicinal Chemistry 59(3), 841-853 (2016).
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| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 337.3 |
| 分子式 | C18H21ClN2 • HCl |
| CAS号 | 14362-31-3 |
| 稳定性 | ≥ 2 years |
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