| 货号 | 18657-50g |
| 描述 | Lactisole is an antagonist of sweet taste receptors, reducing both sweetness intensity and persistence.1,2 It blocks the activation of the sweet taste receptor T1R3 by natural and synthetic sweeteners and increases the inhibition of T1R2 by umami compounds.3,4 Lactisole can be used to explore the roles of these receptors in diverse pathways, including glucose-induced insulin secretion in pancreatic β-cells and the secretion of glucagon-like peptides by enteroendocrine L-cells.3,5,6 |
| 别名 | na-PMP; |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Johnson, C.,Birch, G.G., and MacDougall, D.B. The effect of the sweetness inhibitor 2(-4-methoxyphenoxy)propanoic acid (sodium salt) (Na-PMP) on the taste of bitter-sweet stimuli. Chem.Senses 19(4), 348-358 (1994). 2.Schiffman, S.S.,Booth, B.J.,Sattely-Miller, E.A., et al. Selective inhibition of sweetness by the sodium salt of ±2-(4-methoxyphenoxy)propanoic acid. Chem.Senses 24(4), 439-447 (1999). 3.Hamano, K.,Nakagawa, Y.,Ohtsu, Y., et al. Lactisole inhibits the glucose-sensing receptor T1R3 expressed in mouse pancreatic β-cells. Journal of Endocrinology 226(1), 57-66 (2015). 4.Shim, J.,Son, H.J.,Kim, Y., et al. Modulation of sweet taste by umami compounds via sweet taste receptor subunit hT1R2. PLoS One 10(4), (2015). 5.Ohtsu, Y.,Nakagawa, Y.,Nagasawa, M., et al. Diverse signaling systems activated by the sweet taste receptor in human GLP-1-secreting cells. Molecular and Cellular Endocrinology 394(1-2), 70-79 (2014). 6.Sato, S.,Hokari, R.,Kurihara, C., et al. Dietary lipids and sweeteners regulate glucagon-like peptide-2 secretion. American Journal of Physiology and Gastrointestinal Liver Physiology 304(8), 304-308 (2013). | |
| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 218.2 |
| 分子式 | C10H11O4 • Na |
| CAS号 | 150436-68-3 |
| 稳定性 | ≥ 2 years |
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