| 货号 | 18462-50mg |
| 描述 | Fms-like tyrosine kinase (FLT3) is a cell-surface receptor with important roles in stem cell development, hematopoiesis, and cancer.1,2 FLT3 Inhibitor is a cell-permeable, ATP-competitive inhibitor of FLT3 (IC50 = 27 nM) that blocks the proliferation of myelomonocytic leukemia MV4-11 cells (IC50 = 0.41 µM).3 It is selective for FLT3 over a panel of 22 other kinases. FLT3 Inhibitor synergistically increases the cytotoxicity of an AF4-mimetic peptide against MV4-11 cells.4 |
| 别名 | Fms-like Tyrosine Kinase Inhibitor;TCS 359; |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Grafone, T.,Palmisano, M.,Nicci, C., et al. An overview on the role of FLT3-tyrosine kinase receptor in acute myeloid leukemia: Biology and treatment. Oncol.Rev. 6(1), 64-74 (2012). 2.Lyman, S.D., and Jacobsen, S.E.W. c-kit ligand and Flt3 ligand: Stem/progenitor cell factors with overlapping yet distinct activities. Blood 91(4), 1101-1134 (1998). 3.Patch, R.J.,Baumann, C.A.,Liu, J., et al. Identification of 2-acylaminothiophene-3-carboxamides as potent inhibitors of FLT3. Bioorganic & Medicinal Chemistry Letters 16(12), 3282-3286 (2006). 4.Bennett, C.A.,Winters, A.C.,Barretti, N.N., et al. Molecular targeting of MLL-rearranged leukemia cell lines with the synthetic peptide PFWT synergistically enhances the cytotoxic effect of established chemotherapeutic agents. Leukemia Research 33(7), 937-947 (2009). | |
| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 360.4 |
| 分子式 | C18H20N2O4S |
| CAS号 | 301305-73-7 |
| 稳定性 | ≥ 2 years |
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