AZ 5104
货号：
17994-50mg 基本售价：
5488.0 元 规格：
50 mg
产品信息
概述| 货号 | 17994-50mg |
| 描述 | AZ 5104 is an active, demethylated metabolite of AZD 9291 (Item No. 16237), an irreversible inhibitor of EGFR-sensitizing and T790M resistance mutations (IC50s = 15-17 nM) that spares the wild-type form of the receptor (IC50 = 480 nM).1,2,3 AZ 5104 displays a similar overall activity profile as the parent compound.2,3 |
性能| 供应商 | Cayman |
| 应用文献 |
1.Finlay, M.R.,Anderton, M.,Ashton, S., et al. Discovery of a potent and selective EGFR inhibitor (AZD9291) of both sensitizing and T790M resistance mutations that spares the wild type form of the receptor. Journal of Medicinal Chemistry 57(20), 8249-8267 (2014).
2.Dickinson, P.A.,Vantarini, M.V.,Collier, J., et al. Metabolic disposition of osimertinib in rats, dogs, and humans: Insights into a drug designed to bind covalently to a cysteine residue of epidermal growth factor receptor. Drug Metab. Dispos. 44(8), 1201-1212 (2016).
3.Yates, J.W.,Ashton, S.,Cross, D., et al. Irreversible inhibition of EGFR: Modeling the combined pharmacokinetic-pharmacodynamic relationship of osimertinib and its active metabolite AZ5104. Mol. Cancer Ther. 15(10), 2378-2387 (2016).
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| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 485.6 |
| 分子式 | C27H31N7O2 |
| CAS号 | 1421373-98-9 |
| 稳定性 | ≥ 2 years |
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