| 货号 | 17578-5mg |
| 描述 | Glycogen phosphorylase in the liver, muscle, and brain initiate glycogenolysis by releasing glucose-1-phosphate from glycogen. Glycogen phosphorylase inhibitor is a cell-permeable acyl urea first identified as an inhibitor of human liver glycogen phosphorylase (IC50 = 53 nM).1 It blocks glucagon-induced hepatic glycogenolysis in vivo.1 Glycogen phosphorylase inhibitor has been used to study glycogen utilization in human liver HepG2 cells, retinal explants, and human T lymphocyte Kit 225 cells.2,3,4 |
| 别名 | GPI; |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Klabunde, T.,Wendt, K.U.,Kadereit, D., et al. Acyl ureas as human liver glycogen phosphorylase inhibitors for the treatment of type 2 diabetes. Journal of Medicinal Chemistry 48(20), 6178-6193 (2005). 2.Cheng, A.,Zhang, M.,Gentry, M.S., et al. A role for AGL ubiquitination in the glycogen storage disorders of Lafora and Cori’s disease. Genes & Development 21(19), 2399-2409 (2007). 3.Agathocleous, M.,Love, N.K.,Randlett, O., et al. Metabolic differentiation in retinal cells. Nature Cell Biology 14(8), 859-864 (2012). 4.Arrizabalaga, O.,Lacerda, H.M.,Zubiaga, A.M., et al. Rac1 protein regulates glycogen phosphorylase activation and controls interleukin (IL)-2-dependent T cell proliferation. The Journal of Biological Chemisty 287(15), 11878-11890 (2012). | |
| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 412.8 |
| 分子式 | C17H15ClF2N4O4 |
| CAS号 | 648926-15-2 |
| 稳定性 | ≥ 2 years |
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