| 货号 | 17493-5mg |
| 描述 | NF-κB inhibitor is a synthetic peptide corresponding to the nuclear localization sequence of NF-κB p105 subunit (also known as p50) appended to a hydrophobic sequence to facilitate import into living cells.1 It blocks the nuclear import of p105 in cells treated with activators of NF-κB signaling, including LPS and TNF-α.1 In this way, NF-κB inhibitor blocks gene expression that is regulated by NF-κB.2,3 This peptide is commonly used to evaluate the role of NF-κB signaling in cellular responses.4,5 |
| 别名 | SN50 Peptide; |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Lin, Y.Z.,Tao, S.,Veach, R.A., et al. Inhibition of nuclear translocation of transcription factor NF- k B by a synthetic peptide containing a cell membrane-permeable motif and nuclear localization sequence. The Journal of Biological Chemisty 270(24), 14255-14258 (1995). 2.Torgerson, T.R.,Colosia, A.D.,Donahue, J.P., et al. Regulation of NF-κB, AP-1, NFAT, and STAT1 nuclear import in T lymphocytes by noninvasive delivery of peptide carrying the nuclear localization sequence of NF-κB p50. Journal of Immunology 161(11), 6084-6092 (1998). 3.Kasibhatla, S.,Genestier, L., and Green, D.R. Regulation of fas-ligand expression during activation-induced cell death in T lymphocytes via nuclear factor κB. The Journal of Biological Chemisty 274(2), 987-992 (1999). 4.Methot, L.,Hermann, R.,Tang, Y., et al. Interaction and antagonistic roles of NF-κB and Hes6 in the regulation of cortical neurogenesis. Molecular and Cellular Biology 33(14), 2797-2808 (2013). 5.Wäster, P.,Rosdahl, I., and Ölinger, K. Cell fate regulated by nuclear factor-κB- and activator protein-1-dependent signalling in human melanocytes exposed to ultraviolet A and ultraviolet B. British Journal of Dermatology 171(6), 1336-1346 (2014). | |
| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥95% |
| 计算分子量 | 2781.5 |
| 分子式 | C129H230N36O29S |
| CAS号 | 213546-53-3 |
| 稳定性 | ≥ 2 years |
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