| 货号 | 17345-1g |
| 描述 | Rhein is an anti-inflammatory anthraquinone found in rhubarb and is the bioactive derivative of its prodrug diacerein (Item No. 11710). At 10 µM, rhein inhibits IL-1β signaling, suppressing signaling through NF-κB, and reduces the expression of the matrix metalloproteases MMP-1 and MMP-13.1 It inhibits IKKβ (IC50 = 11.8 µM), decreasing iNOS and IL-6 expression in LPS-stimulated macrophages but paradoxically increasing TNF-α, IL-1β, and HMBG1 expression.2 Rhein shows efficacy against pancreatic fibrosis, chronic pancreatitis, and hyperglycemia-induced pancreatic β-cell apoptosis.3,4 It also inhibits angiogenesis of breast cancer cells under normoxic and hypoxic conditions.5 |
| 别名 | NSC 38629;Rheic Acid; |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Domagala, F.,Martin, G.,Bogdanowicz, P., et al. Inhibition of interleukin-1β-induced activation of MEK/ERK pathway and DNA binding of NF-κB and AP-1: Potential mechanism for Diacerein effects in osteoarthritis. Biorheology 43(3-4), 577-587 (2006). 2.Gao, Y.,Chen, X.,Fang, L., et al. Rhein exerts pro- and anti-inflammatory actions by targeting IKKβ inhibition in LPS-activated macrophages. Free Radical Biology & Medicine 72, 104-112 (2014). 3.Tsang, S.W.,Zhang, H.,Lin, C., et al. Rhein, a natural anthraquinone derivative, attenuates the activation of pancreatic stellate cells and ameliorates pancreatic fibrosis in mice with experimental chronic pancreatitis. PLoS One 8(12), 1-15 (2013). 4.Sayre, L.M.,Larson, D.L.,Takemori, A.E., et al. Design and synthesis of naltrexone-derived affinity labels with nonequilibrium opioid agonist and antagonist activities. Evidence for the existence of different μ receptor subtypes in different tissues. Journal of Medicinal Chemistry 27(10), 1325-1335 (1984). 5.Fernand, V.E.,Losso, J.N.,Traux, R.E., et al. Rhein inhibits angiogenesis and the viability of hormone-dependent and -independent cancer cells under normoxic or hypoxic conditions in vitro. Chemico-Biological Interactions 192(3), 220-232 (2011). | |
| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥95% |
| 计算分子量 | 284.2 |
| 分子式 | C15H8O6 |
| CAS号 | 478-43-3 |
| 稳定性 | ≥ 2 years |
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