| 货号 | 16945-50mg |
| 描述 | SCH 202676 is a reversible inhibitor of both agonist and antagonist binding to diverse G protein-coupled receptors (GPCRs).1 It blocks the binding of radiolabeled ligands to human opioid, adrenergic, muscarinic, dopaminergic, adenosine, and purinergic receptors.1,2,3 It displays IC50 values of 0.1 to 1.8 µM for modulating ligand binding.1,2 SCH 202676 may modulate GPCRs via thiol modification.4 |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Fawzi, A.B.,Macdonald, D.,Benbow, L.L., et al. SCH-202676: An allosteric modulator of both agonist and antagonist binding to G protein-coupled receptors. Molecular Pharmacology 59(1), 30-37 (2001). 2.Gao, Z.G.,Kim, S.K.,Ijzerman, A.P., et al. Allosteric modulation of the adenosine family of receptors. Mini Rev.Med.Chem. 5(6), 545-553 (2005). 3.Lanzafame, A., and Christopoulos, A. Investigation of the interaction of a putative allosteric modulator, N-(2,3-diphenyl-1,2,4-thiadiazole-5-(2H)-ylidene) methanamine hydrobromide (SCH-202676), with M1 muscarinic acetylcholine receptors. Journal of Pharmacology and Experimental Therapeutics 308(3), 830-837 (2004). 4.Lewandowicz, A.M.,Vepsäläinen, J., and Laitinen, J.T. The allosteric modulator SCH-202676 disrupts G protein-coupled receptor function via sulphydryl-sensitive mechanisms. British Journal of Pharmacology 147(4), 422-429 (2006). | |
| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥95% |
| 计算分子量 | 348.3 |
| 分子式 | C15H13N3S • HBr |
| CAS号 | 265980-25-4 |
| 稳定性 | ≥ 2 years |
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