| 货号 | 15557-10mg |
| 描述 | Ramiprilat is the active metabolite of ramipril (Item No. 15558) and functions as an angiotensin-converting enzyme inhibitor (pKi = 9.08 in human heart) to suppress the conversion of angiotensin I to angiotensin II and the degradation of bradykinin, thereby preventing vasoconstriction.1,2 Furthermore, ramiprilat is reported to interfere with the targeting of B2 kinin receptors to endothelial cell membranes further preventing bradykinin signaling.2 In addition to its cardioprotective effects in both animal models and clinical studies, ramiprilat has been reported to inhibit matrix metalloproteinase-3 and -9 activity in isolated Crohn’s disease fistulas.3,4 |
| 别名 | Ramipril Diacid; |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Vago, T.,Bevilacqua, M.,Conci, F., et al. Angiotensin converting enzyme binding sites in human heart and lung: Comparison with rat tissues. British Journal of Pharmacology 107(3), 821-825 (1992). 2.Benzing, T.,Fleming, I.,Blaukat, A., et al. Angiotensin-converting enzyme inhibitor ramiprilat interferes with the sequestration of the B2 kinin receptor within the plasma membrane of native endothelial cells. Circulation 99(15), 2034-2040 (1999). 3.Yusuf, S.,Sleight, P.,Pogue, J., et al. Effects of an angiotensin-converting-enzyme inhibitor, ramipril, on cardiovascular events in high-risk patients. New England Journal of Medicine 342(3), 145-153 (2000). 4.Efsen, E.,Særmark, T.,Hansen, A., et al. Ramiprilate inhibits functional matrix metalloproteinase activity in Crohn’s disease fistulas. Basic & Clinical Pharmacology & Toxicology 109(3), 208-216 (2011). | |
| 运输条件 | Wet ice in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 388.5 |
| 分子式 | C21H28N2O5 |
| CAS号 | 87269-97-4 |
| 稳定性 | ≥ 2 years |
| 本官网所有报价均为常温或者蓝冰运输价格，如有产品需要干冰运输，需另外加收干冰运输费。 |