FR180204
货号：
15544-25mg 基本售价：
5488.0 元 规格：
25 mg
产品信息
概述| 货号 | 15544-25mg |
| 描述 | The extracellular regulated kinases 1 and 2 (ERK1/2) are functionally redundant kinases activated by a variety of growth factors and mitogens.1 FR180204 is a potent cell-permeable inhibitor of ERK1 and ERK2 (Ki = 310 and 140 nM, respectively).2 It is much less effective against p38α (IC50 = 10 µM) and does not inhibit a range of other serine/threonine or tyrosine kinases.2 FR180204 blocks ERK-mediated signaling from TGF-β to AP-1 (IC50 = 3.1 μM).2 It attenuates delayed-type hypersensitivity in collagen-immunized mice and ameliorates collagen-induced arthritis in mice.3 |
| 别名 | ERK Inhibitor II; |
性能| 供应商 | Cayman |
| 应用文献 |
1.Seger, R. and Krebs, E.G. The MAPK signaling cascade. The FASEB Journal 9, 726-735 (1995).
2.Ohori, M.,Kinoshita, T.,Okubo, M., et al. Identification of a selective ERK inhibitor and structural determination of the inhibitor-ERK2 complex. Biochemical and Biophysical Research Communications 336(1), 357-363 (2005).
3.Ohori, M.,Takeuchi, M.,Maruki, R., et al. FR180204, a novel and selective inhibitor of extracellular signal-regulated kinase, ameliorates collagen-induced arthritis in mice. Naunyn-Schmiedebergs Archives of Pharmacology 374(4), 311-316 (2007).
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| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 327.3 |
| 分子式 | C18H13N7 |
| CAS号 | 865362-74-9 |
| 稳定性 | ≥ 2 years |
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