Gly-Phe-β-naphthylamide
货号：
14634-500mg 基本售价：
5488.0 元 规格：
500 mg
产品信息
概述| 货号 | 14634-500mg |
| 描述 | Cathepsin C is a lysosomal cysteine protease with broad exopeptidase activity that progressively removes dipeptides from various protein and polypeptides substrates.1 Aside from its role in post-translational processing, cathepsins may also participate in apoptotic signaling pathways by targeting cytosolic caspases and proapoptotic proteins.2 Gly-Phe-β-naphthylamide is a substrate of cathepsin C that accumulates within the lysosome. Hydrolysis by cathepsin C degrades Gly-Phe-β-naphthylamide into fragments that do not easily diffuse through the lysosomal membrane, leading to a loss of lysosome membrane integrity.3 This compound has been used to study intralysosomal hydrolysis, lysosomal membrane permeability, and the function of cathepsin C.1,3 At 50 μM, Gly-Phe-β-naphthylamide can inhibit the cathepsin-dependent activation of caspase-8.2 |
| 别名 | H-Gly-Phe-BNA; |
性能| 供应商 | Cayman |
| 应用文献 |
1.Qiu, G.F.,Feng, H.Y. and Yamano, K. Expression and purification of active recombinant cathepsin C (dipeptidyl aminopeptidase I) of kuruma prawn Marsupenaeus japonicus in insect cells. Journal of Biomedicine and Biotechnology 2009, 1-6 (2009).
2.Baumgartner, H.K.,Gerasimenko, J.V.,Thorne, C., et al. Caspase-8-mediated apoptosis induced by oxidative stress is independent of the intrinsic pathway and dependent on cathepsins. American Journal of Physiology and Gastrointestinal Liver Physiology 293(1), 296-307 (2007).
3.Jadot, M.,Colmant, C.,Wattiaux-De Coninck, S., et al. Intralysosomal hydrolysis of glycyl-L-phenylalanine 2-naphthylamide. Biochemistry Journal 219(3), 965-970 (1984).
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| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥95% |
| 计算分子量 | 347.4 |
| 分子式 | C21H21N3O2 |
| CAS号 | 21438-66-4 |
| 稳定性 | ≥ 2 years |
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