CAY10606
货号：
13381-10mg 基本售价：
5488.0 元 规格：
10 mg
产品信息
概述| 货号 | 13381-10mg |
| 描述 | 5-Lipoxygenase (5-LO) initiates the synthesis of leukotrienes (LTs) from arachidonic acid, primarily in certain leukocyte populations. CAY10606 is a potent, reversible inhibitor of 5-LO, both in cell-free assays (IC50 = 86 nM) and in intact neutrophils (IC50 = 230 nM).1 It prevents the production of LTs in whole blood, whether 5-LO is activated with the calcium ionophore A23187 (IC50 = 1.6 μM) or formyl peptide (fMLP) following priming with lipopolysaccharide (IC50 = 830 nM). In rats subjected to carrageenan-induced pleurisy, CAY10606 significantly reduces both LT biosynthesis and the inflammatory reaction.1 |
性能| 供应商 | Cayman |
| 应用文献 |
1.Karg, E.M.,Luderer, S.,Pergola, C., et al. Structural optimization and biological evaluation of 2-substituted 5-hydroxyindole-3-carboxylates as potent inhibitors of human 5-lipoxygenase. Journal of Medicinal Chemistry 52, 3474-3483 (2009).
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| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 379.8 |
| 分子式 | C22H18ClNO3 |
| CAS号 | 1159576-98-3 |
| 稳定性 | ≥ 2 years |
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