Ganglioside GQ1b (sodium salt)
货号：
15589-500ug 基本售价：
5475.0 元 规格：
500 ug
产品信息
概述| 货号 | 15589-500ug |
| 描述 | Gangliosides are formed from a glycosphingolipid combined with one or more sialic acids at the oligosaccharide chain. They are anchored at the outer surface of the plasma membrane where they pack densely with cholesterol to form lipid microdomains that modulate both intra- and inter-cellular signaling events. Ganglioside GQ1b is a tetrasialoganglioside that is characterized by having two sialic residues linked to the inner galactose unit. At 5 nM, it can stimulate an ecto-type (cell-surface) protein phosphorylation system in the human neuroblastoma cell line GOTO.1 Ganglioside GQ1b has been reported to promote neurite outgrowth during early neuronal differentiation by activating the ERK1/2 MAP kinase pathway.2 It has also been shown to initiate keratinocyte differentiation through phophoinositide turnover.3 |
性能| 供应商 | Cayman |
| 应用文献 |
1.Tsuji, S.,Yamashita, T. and Nagai, Y. A novel, carbohydrate signal-mediated cell surface protein phosphorylation: Ganglioside GQ1b stimulates ecto-protein kinase activity on the cell surface of a human neuroblastoma cell line, GOTO. Journal of Biochemistry 104(4), 498-503 (1988).
2.Kwak, D.H.,Jin, J.W.,Ryu, J.S., et al. Regulatory roles of ganglioside GQ1b in neuronal cell differentiation of mouse embryonic stem cells. BMB Rep. 44(12), 799-804 (2011).
3.Yada, Y.,Okano, Y. and Nozawa, Y. Ganglioside GQ1b-induced terminal differentiation in cultured mouse keratinocytes. Phosphoinositide turnover forms the onset signal. Biochemistry Journal 279(Pt 3), 665-670 (1991).
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| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 2508.5 |
| 分子式 | C106H178N6O55 • 4Na |
| CAS号 | 68652-37-9 |
| 稳定性 | ≥ 2 years |
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