| 货号 | 16605-25mg |
| 描述 | Actinonin is a peptidomimetic antibiotic produced by Actinomyces that inhibits aminopeptidases. It inhibits the following matrix metalloproteinases (MMPs): MMP-1 (Ki = 300 nM), MMP-2 (IC50 = ~90 nM), MMP-3 (Ki = 1,700 nM), MMP-7 (IC50 = ~3,500 nM), MMP-8 (Ki = 130 nM), MMP-9 (Ki = 330 nM), MMP-10 (IC50 = ~500 nM), MMP-12 (IC50 = ~350 nM), and MMP-13 (IC50 = ~100 nM), but not MMP-14 (IC50 > 1 mM).1 Actinonin acts as an herbicide by targeting plastid peptide deformylase, an enzyme required for N-terminal processing of plastid-encoded proteins.2 Actinonin has also been identified as an effective inhibitor of human meprin α (Ki = 20 nM), a zinc endopeptidase that cleaves matrix proteins.3 More recently actinonin has been shown to inhibit tumor cell invasion and matrix degradation and to induce apoptosis in animal models by targeting human mitochondrial peptide deformylase.4 |
| 别名 | (-)-Actinonin;Ro 06-1467; |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Wahl, R.C.,Pulvino, T.A.,Mathiowetz, A.M., et al. Hydroxamate inhibitors of human gelatinase B (92 kDa). Bioorganic & Medicinal Chemistry Letters 5(4), 349-352 (1995). 2.Duke, S.O. and Dayan, F.E. Modes of action of microbially-produced phytotoxins. Toxins (Basel) 3(8), 1038-1064 (2011). 3.Kruse, M.N.,Becker, C.,Lottaz, D., et al. Human meprin α and β homo-oligomers: Cleavage of basement membrane proteins and sensitivity to metalloprotease inhibitors. Biochemistry Journal 378(1), 383-389 (2004). 4.Lee, M.D.,She, Y.,Soskis, M.J., et al. Human mitochondrial peptide deformylase, a new anticancer target of actinonin-based antibiotics. Journal of Clinical Investigation 114(8), 1107-1116 (2004). | |
| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 385.5 |
| 分子式 | C19H35N3O5 |
| CAS号 | 13434-13-4 |
| 稳定性 | ≥ 2 years |
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