Ro 61-8048
货号：
15199-50mg 基本售价：
5460.0 元 规格：
50 mg
产品信息
概述| 货号 | 15199-50mg |
| 描述 | The kynurenine pathway mediates the metabolism of L-tryptophan to NAD+ and is particularly important in neurophysiology. Ro 61-8048 is a potent inhibitor of kynurenine 3-hydroxylase (IC50 = 37 nM), preventing the conversion of kynurenine (Item No. 11305) to 3-hydroxy kynurenine.1 Ro 61-8048 inhibition of kynurenine 3-hydroxylase reduces ischemia-mediated neuronal damage in tissues.1,2 Ro 61-8048 can be used in vivo by direct injection.3 |
性能| 供应商 | Cayman |
| 应用文献 |
1.Röver, S.,Cesura, A.M.,Huguenin, P., et al. Synthesis and biochemical evaluation of N-(4-phenylthiazol-2-yl)benzenesulfonamides as high-affinity inhibitors of kynurenine 3-hydroxylase. Journal of Medicinal Chemistry 40(26), 4378-4385 (1997).
2.Carpenedo, R.,Meli, E.,Peruginelli, F., et al. Kynurenine 3-mono-oxygenase inhibitors attenuate post-ischemic neuronal death in organotypic hippocampal slice cultures. Journal of Neurochemistry 82(6), 1465-1471 (2002).
3.Hamann, M.,Sander, S.E. and Richter, A. Effects of the kynurenine 3-hydroxylase inhibitor Ro 61-8048 after intrastriatal injections on the severity of dystonia in the dtsz mutant. European Journal of Pharmacology 586(1-3), 156-159 (2008).
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| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 421.4 |
| 分子式 | C17H15N3O6S2 |
| CAS号 | 199666-03-0 |
| 稳定性 | ≥ 2 years |
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