| 货号 | 14593-50mg |
| 描述 | Calpeptin is a cell-penetrating peptide inhibitor of calpain (IC50 = 5 nM) which completely abolishes calpain activity in platelets.1,2,3 In this way, it inhibits both collagen- and thrombin-induced aggregation of platelets.4 Calpeptin is also a potent inhibitor of cathepsin K (IC50 = 0.11 nM).5 |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Tsujinaka, T.,Kajiwara, Y.,Kambayashi, J., et al. Synthesis of a new cell penetrating calpain inhibitor (calpeptin). Biochemical and Biophysical Research Communications 153, 1201-1208 (1988). 2.Iqbal, M.,Messina, P.A.,Freed, B., et al. Subsite requirements for peptide aldehyde inhibitors of human calpain I. Bioorganic & Medicinal Chemistry Letters 7(5), 539-544 (1997). 3.Leung, D.,Abbenante, G. and Fairlie, D.P. Protease inhibitors: Current status and future prospects. J. Med. Chem. 43(3), 305-341 (2000). 4.Mehdi, S. Cell-penetrating inhibitors of calpain. Trends in Biochemical Sciences 16(4), 150-153 (1991). 5.Catalano, J.G.,Deaton, D.N.,Long, S.T., et al. Design of small molecule ketoamide-based inhibitors of cathepsin K. Bioorganic & Medicinal Chemistry Letters 14(3), 719-722 (2004). | |
| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥90% |
| 计算分子量 | 362.5 |
| 分子式 | C20H30N2O4 |
| CAS号 | 117591-20-5 |
| 稳定性 | ≥ 2 years |
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