GSK805
货号：
9002444-10mg 基本售价：
5390.0 元 规格：
10 mg
产品信息
概述| 货号 | 9002444-10mg |
| 描述 | GSK805 is a potent, orally bioavailable retinoid-related orphan receptor gamma t (RORγt) inverse agonist that interacts with the receptors putative ligand binding domain without exerting significant effects on DNA binding.1 It inhibits the expression of IL-17 (at 0.5 µM) in naïve CD4+ T cells activated under Th17-cell-polarizing conditions and affects the broader RORγt-dependent gene network, inhibiting the development and pathogenic function of Th17 cells. GSK805 significantly reduces the severity of experimental autoimmune encephalomyelitis (EAE), a mouse model of multiple sclerosis, when given orally to the hosts at 10 mg/kg daily beginning at the time of disease induction. |
性能| 供应商 | Cayman |
| 应用文献 |
1.Xiao, S.,Yosef, N.,Yang, J., et al. Small-molecule RORγt antagonists inhibit T helper 17 cell transcriptional network by divergent mechanisms. Immunity 40(4), 477-489 (2014).
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| 运输条件 | Wet ice in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 532.4 |
| 分子式 | C23H18Cl2F3NO4S |
| CAS号 | 1426802-50-7 |
| 稳定性 | ≥ 2 years |
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