| 货号 | 21491-50mg |
| 描述 | Importazole is a cell-permeable inhibitor of importin-β, which transports cargo molecules bearing a nuclear localization signal into the nucleus.1 Importazole prevents nuclear import of GPF-tagged nuclear factor of activated T cells (NFAT-GFP) in HEK293 cells (IC50 = 15 μM), which is reversible upon importazole washout.1 Importazole does not interfere with transportin-mediated nuclear import or chromosomal maintenance 1 (CRM1)-mediated nuclear export.1 Importazole inhibits nuclear import of topoisomerase IIβ binding protein 1 (TopBP1) in Xenopus egg extracts and of NF-κB in multiple myeloma cells.2,3 It also induces defects in spindle and microtubule formation in vitro.4 |
| 别名 | IPZ; |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Soderholm, J.F.,Bird, S.L.,Kalab, P., et al. Importazole, a small molecule inhibitor of the transport receptor importin-β. ACS Chem Biol. 6(7), 700-708 (2011). 2.Bai, L.,Michael, W.M., and Yan, S. Importin β-dependent nuclear import of TopBP1 in ATR-Chk1 checkpoint in Xenopus egg extracts. Cell. Signal. 26(5), 857-867 (2015). 3.Yan, W.Q.,Du, J.,Jiang, H., et al. Effect of nuclear receptor inhibitor importazole on the proliferation and apoptosis of multiple myeloma cells. Zhonghua Xue Ye Xue Za Zhi 34(4), 323-326 (2013). 4.Bird, S.L., and Weis, K. RanGTP and CLASP1 cooperate to position the mitotic spindle. Mol. Biol. Cell 24(16), 2506-2514 (2013). | |
| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 318.4 |
| 分子式 | C20H22N4 |
| CAS号 | 662163-81-7 |
| 稳定性 | ≥ 2 years |
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