Stiripentol
货号：
17781-50mg 基本售价：
5390.0 元 规格：
50 mg
产品信息
概述| 货号 | 17781-50mg |
| 描述 | Stiripentol is a third-generation anti-epileptic drug that is known to inhibit the synaptosomal uptake of GABA, increasing the activation of GABAAreceptors.1,2 It also inhibits microsomal cytochrome P450 (CYP) isoforms CYP3A4, CYP1A2, and CYP2C19.1 More recently, stiripentol and analogs have been shown to inhibit lactate dehydrogenase (LDH), blocking both lactate to pyruvate and pyruvate to lactate conversions by human LDH isoforms 1 and 5 at 500 µM.3 In this way, stiripentol mimics ketogenic diets, which can also lower lactate levels in the brain and prevent seizures.3 |
| 别名 | BCX 2600; |
性能| 供应商 | Cayman |
| 应用文献 |
1.Luszczki, J.J. Third-generation antiepileptic drugs: Mechanisms of action, pharmacokinetics and interactions. Pharmacological Reports 6, 197-216 (2009).
2.Fisher, J.L. The effects of stiripentol on GABAA receptors. Epilepsia 52(0 2), 76-78 (2011).
3.Sada, N.,Lee, S.,Katsu, T., et al. Targeting LDH enzymes with a stiripentol analog to treat epilepsy. Science 347(6228), 1362-1367 (2015).
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| 运输条件 | Wet ice in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 234.3 |
| 分子式 | C14H18O3 |
| CAS号 | 49763-96-4 |
| 稳定性 | ≥ 2 years |
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