PKA Inhibitor (5-24)
货号：
15996-5mg 基本售价：
5390.0 元 规格：
5 mg
产品信息
概述| 货号 | 15996-5mg |
| 描述 | PKI PKA Inhibitor (5-24) is a synthetic peptide inhibitor of PKA (cAMP-dependent protein kinase) (Ki = 2.3 nM) derived from the active site of the skeletal muscle inhibitor protein.1 It mimics the protein substrate by binding to the catalytic site through the arginine-cluster basic subsite.1 The prominent enzyme-substrate interaction site occurs where PKA catalytic subunit residues Tyr235 and Phe239 form a sandwich-like structure with residue Phe10 of PKI (5-24).2 |
| 别名 | PKI (5-24);Protein Kinase A Inhibitor (5-24); |
性能| 供应商 | Cayman |
| 应用文献 |
1.Cheng, H.C.,Kemp, B.E.,Pearson, R.B., et al. A potent synthetic peptide inhibitor of the cAMP-dependent protein kinase. The Journal of Biological Chemisty 261(3), 989-992 (1986).
2.Bossemeyer, D.,Engh, R.A.,Kinzel, V., et al. Phosphotransferase and substrate binding mechanism of the cAMP-dependent protein kinase catalytic subunit from porcine heart as deduced from the 2.0 Å structure of the complex with Mn2+ adenylyl imidodiphosphate and inhibitor peptide PKI(5-24). EMBO Journal 12(3), 849-859 (1993).
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| 运输条件 | Wet ice in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥95% |
| 计算分子量 | 2222.4 |
| 分子式 | C94H148N32O31 |
| CAS号 | 99534-03-9 |
| 稳定性 | ≥ 2 years |
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