| 货号 | 10011362-100ug |
| 描述 | Leukotrienes (LTs) are a group of acute inflammatory mediators derived from arachidonic acid in leukocytes. The majority of these metabolites are formed through the 5-lipoxygenase (5-LO) pathway.114,15-LTE4 is a metabolite of 14,15-LTC4 and 14,15-LTD4, an alternate class of LTs synthesized by a pathway involving the dual actions of 15- and 12-LOs on arachidonic acid via 15-HpETE and 14,15-LTA4intermediates.2,3,4,5 These metabolites are classified as eoxins because they are formed mostly by eosinophils.4 Mast cells and nasal polyps can synthesize 14,15-LTC4 as well, however metabolism to 14,15-LTE4 in these cells and tissue has not been documented. 14,15-LTE4 increases vascular permeability of human endothelial cell monolayers with about 10-fold less potency than LTC4, but approximately 100-fold greater potency than histamine.4 |
| 别名 | Eoxin E4;EXE4;14,15-LTE4; |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Luo, M.,Lee, S. and Brock, T.G. Leukotriene synthesis by epithelial cells. Histology and Histopathology 18, 587-595 (2003). 2.Yokoyama, C.,Shinjo, F.,Yoshimoto, T., et al. Arachidonate 12-lipoxygenase purified from porcine leukocytes by immunoaffinity chromatography and its reactivity with hydroperoxyeicosatetraenoic acids. The Journal of Biological Chemisty 261, 16714-16721 (1986). 3.Bryant, R.W.,Schewe, T.,Rapoport, S.M., et al. Leukotriene formation by a purified reticulocyte lipoxygenase enzyme. Conversion of arachidonic acid and 15-hydroperoxyeicosatetraenoic acid to 14,15-leukotriene A4. The Journal of Biological Chemisty 260, 3548-3555 (1985). 4.Feltenmark, S.,Gautam, N.,Brunnström, Å., et al. Eoxins are proinflammatory arachidonic acid metabolites produced via the 15-lipoxygenase-1 pathway in human eosinophils and mast cells. Proceedings of the National Academy of Sciences of the United States of America 105(2), 680-685 (2008). 5.Sailesh, S.,Kumar, Y.V.K.,Prasad, M., et al. Sheep uterus dual lipoxygenase in the synthesis of 14,15-leukotrienes. Archives of Biochemistry and Biophysics 315(2), 362-368 (1994). | |
| 运输条件 | Dry ice in continental US; may vary elsewhere |
| 存放说明 | -80 |
| 纯度 | ≥97% |
| 计算分子量 | 439.6 |
| 分子式 | C23H37NO5S |
| CAS号 | 1000852-57-2 |
| 稳定性 | ≥ 1 year |
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