Ezetimibe
货号：
16331-250mg 基本售价：
5376.0 元 规格：
250 mg
产品信息
概述| 货号 | 16331-250mg |
| 描述 | Ezetimibe inhibits intestinal cholesterol absorption by preventing cholesterol uptake by the Niemann-Pick C1-like 1 (NPC1L1) protein, a cholesterol transporter located in the apical membrane of enterocytes.1,2 Upon oral administration ezetimibe undergoes rapid glucuronidation in the intestine where its glucuronide binds NPC1L1 with KD values of 12,000, 540, 40, and 220 nM in mouse, rat, rhesus monkey, and human, respectively.1,2 It exhibits IC50 values of 0.0005-0.05 mg/kg in various animal models, selectively blocking cholesterol absorption without inhibiting pancreatic lipolytic enzyme activities in the intestinal lumen, affecting bile acid micelle solubilization of cholesterol, or interfering with the absorption of triglycerides, fatty acids, or bile acids.1 |
| 别名 | Ezetrol;SCH 58235;Zetia®; |
性能| 供应商 | Cayman |
| 应用文献 |
1.Wang, D.Q. Regulation of intestinal cholesterol absorption. Annual Reviews of Physiology 69, 221-248 (2011).
2.Garcia-Calvo, M.,Lisnock, J.,Bull, H.G., et al. The target of ezetimibe is Niemann-Pick C1-like 1 (NPC1L1). Proceedings of the National Academy of Sciences of the United States of America 102(23), 8132-8137 (2005).
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| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 409.4 |
| 分子式 | C24H21F2NO3 |
| CAS号 | 163222-33-1 |
| 稳定性 | ≥ 2 years |
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