| 货号 | 5794/50 |
| 别名 | 6-Fluoro-3-[(1E)-2-(2H-tetrazol-5-y |
| 供应商 | Tocris |
| 生物活性 | Selective tryptophan 2,3-dioxygenase (TDO) inhibitor (IC50 values are 0.62 and 2 μM for human and mouse TDO, respectively). Exhibits selectivity for TDO over IDO, MAO-A, MAO-B, and a panel of receptors and transporters. Reduces growth of TDO-expressing P815 mastocytoma tumors in mice. Orally bioavailable. |
| 运输条件 | Blue Ice |
| 存放说明 | -20℃ |
| 纯度 | >98 % |
| 计算分子量 | 229.21 |
| 分子式 | C11H8FN5 |
| 可溶性/溶解性 | Soluble to 100 mM in DMSO and to 20 mM in ethanol with gentle warming |
| 参考文献 | Pilotteet al (2012) Reversal of tumoral immune resistance by inhibition of tryptophan 2,3-dioxygenase. Proc.Natl.Acad.Sci.U.S.A. 109 2497. PMID: 22308364. Dolusićet al (2011) Tryptophan 2,3-dioxygenase (TDO) inhibitors. 3-(2-(pyridyl)ethenyl)indoles as potential anticancer immunomodulators. J.Med.Chem. 54 5320. PMID: 21726069. |