| 货号 | 9001937-100ug |
| 描述 | 12(S)-HETE (Item No. 34570) is the predominant lipoxygenase product of mammalian platelets.1 It enhances tumor cell adhesion to endothelial cells, fibronectin, and the subendothelial matrix at 0.1 µM.2,3 12(S)-HETE-19,20-alkyne is a form of 12(S)-HETE with an ω-terminal alkyne. The terminal alkyne group can be used in click chemistry linking reactions, to tag 12(S)-HETE with fluorescent or biotinylated labels for analysis of its metabolism and biological activity.4,5 |
| 别名 | Click Tag™ 12(S)-HETE-19,20-alkyne; |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Hamberg, M., and Samuelsson, B. Prostaglandin endoperoxides. Novel transformations of arachidonic acid in human platelets. Proceedings of the National Academy of Sciences of the United States of America 71, 3400-3404 (1974). 2.Grossi, I.M.,Fitzgerald, L.A.,Umbarger, L.A., et al. Bidirectional control of membrane expression and/or activation of the tumor cell IRGpIIb/IIIa receptor and tumor cell adhesion by lipoxygenase products of arachidonic acid and linoleic acid. Cancer Research 49, 1029-1037 (1989). 3.Honn, K.V.,Nelson, K.K.,Renaud, C., et al. Fatty acid modulation of tumor cell adhesion to microvessel endothelium and experimental metastasis. Prostaglandins 44, 413-429 (1992). 4.Kolb, H.C., and Sharpless, K.B. The growing impact of click chemistry on drug discovery. Drug Discovery Today 8(24), 1128-1137 (2003). 5.Lutz, J.F., and Zarafshani, Z. Efficient construction of therapeutics, bioconjugates, biomaterials and bioactive surfaces using azide-alkyne "click" chemistry. Advanced Drug Delivery Reviews 60, 958-970 (2008). | |
| 运输条件 | Wet ice in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥97% |
| 计算分子量 | 316.4 |
| 分子式 | C20H28O3 |
| 稳定性 | ≥ 1 year |
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