Encorafenib
货号：
16994-5mg 基本售价：
5320.0 元 规格：
5 mg
产品信息
概述| 货号 | 16994-5mg |
| 描述 | B-Raf is a MAP kinase kinase kinase, which functions downstream of Ras family GTPases to activate MEK1/2 and ERK1/2 signaling. A mutation of B-Raf in exon 15 at codon 600 where a valine is substituted by glutamic acid (V600E) has been linked to melanoma.1 Encorafenib is a selective inhibitor of B-RafV600E mutant melanoma cell proliferation (EC50 = 4 nM) with little activity against wild-type B-Raf or a panel of 100 other kinases (IC50s = 900 nM).2 At oral doses of 6 mg/kg in human melanoma xenograft models, encorafenib was shown to decrease phosphorylation of the B-Raf substrate MEK.3 |
| 别名 | LGX818; |
性能| 供应商 | Cayman |
| 应用文献 |
1.Tronnier, M., and Mitteldorf, C. Treating advanced melanoma: Current insights and opportunities. Cancer Manag.Res. 6, 349-356 (2014).
2.Stuart, D.D.,Li, N.,Poon, D.J., et al. Preclinical profile of LGX818: A potent and selective RAF kinase inhibitor. Cancer Research 72, (2012).
3.Huang, T.,Karsy, M.,Zhuge, J., et al. B-Raf and the inhibitors: From bench to bedside. J.Hematol.Oncol. 6, 1-9 (2013).
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| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 540 |
| 分子式 | C22H27ClFN7O4S |
| CAS号 | 1269440-17-6 |
| 稳定性 | ≥ 2 years |
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