| 货号 | 21417-1mg |
| 描述 | Cyclic ADP-ribose (cADP-ribose) is an endogenous metabolite of NAD+ that mobilizes the release of stored Ca2+ in the endoplasmic reticulum via ryanodine receptors in various cell types.1,2,3,4,5 This second messenger is generated via the cADP-ribose synthases CD38 and CD157.6,5,7 cADP-Ribose may also trigger the cell surface Ca2+ influx channel TRPM2 in a temperature-dependent manner.8In vitro, cADP-ribose modulates Ca2+ signaling in rat and mouse cardiomyocytes treated with isoproterenol (Item No. 15592), and treatment with this metabolite at 100 µM under heat stress conditions induces the release of oxytocin (Item No. 11799) from the mouse hypothalamus.9,4 |
| 别名 | cADP-Ribose;cADPR; |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Lee, H.C.,Walseth, T.F.,Bratt, G.T., et al. Structural determination of a cyclic metabolite of NAD+ with intracellular Ca2+ -mobilizing activity. J. Biol. Chem. 264(3), 1608-1615 (1989). 2.Houtkooper, R.H.,Cantó, C.,Wanders, R.J., et al. The secret life of NAD+: An old metabolite controlling new metabolic signaling pathways. Endocr. Rev. 31(2), 194-223 (2010). 3.Lee, H.C. Cyclic ADP-ribose and nicotinic acid adenine dinucleotide phosphate (NAADP) as messengers for calcium mobilization. J. Biol. Chem. 287(38), 31633-31640 (2012). 4.Gul, R.,Park, D.-R.,Shawl, A.I., et al. Nicotinic acid adenine dinucleotide phosphate (NAADP) and cyclic ADP-ribose (cADPR) mediate Ca2+ signaling in cardiac hypertrophy induced by β-adrenergic stimulation. PLoS One 11(3), e0149125 (2016). | |
| 运输条件 | Dry ice in continental US; may vary elsewhere |
| 存放说明 | -80 |
| 纯度 | ≥98% |
| 计算分子量 | 541.3 |
| 分子式 | C15H21N5O13P2 |
| CAS号 | 119340-53-3 |
| 稳定性 | ≥ 2 years |
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