PAF Acetylhydrolase (human recombinant)
货号：
10279-100ug 基本售价：
5292.0 元 规格：
100 ug
产品信息
概述| 货号 | 10279-100ug |
| 描述 | Platelet-activating factor (PAF) is an important lipid mediator involved in inflammation. PAF-acetylhydrolase (PAF-AH) is an extracellular phospholipase A2 which hydrolyzes the acetyl group at the sn-2 position of phospholipids.1 Two main types of PAF-AH have been characterized, namely the secreted (i.e. plasma) and intracellular enzymes, which are encoded on individual genes and share only 41% homology at the amino acid level.2,3 Cayman’s PAF-AH is the secreted calcium-independent isoform. PAF deacetylation by PAF-AH causes loss of biological activity, making PAF-AH potentially useful as an anti-inflammation therapy. |
| 别名 | PAF-AH;Lp-PLA2;Platelet-activating Factor Acetylhydrolase;Lipoprotein PLA2; |
性能| 供应商 | Cayman |
| 应用文献 |
1.Tjoelker, L.W.,Wilder, C.,Eberhardt, C., et al. Anti-inflammatory properties of a platelet-activating factor acetylhydrolase. Nature 374, 549-553 (1995).
2.Stafforini, D.M.,McIntyre, T.M.,Zimmerman, G.A., et al. Platelet-activating factor acetylhydrolases. The Journal of Biological Chemisty 272, 17895-17898 (1997).
3.Hattori, K.,Adachi, H.,Matsuzawa, A., et al. cDNA cloning and expression of intracellular platelet-activating factor (PAF) acetylhydrolase II. Its homology with plasma PAF acetylhydrolase. The Journal of Biological Chemisty 271, 33032-33038 (1996).
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| 运输条件 | Dry ice in continental US; may vary elsewhere |
| 存放说明 | -80 |
| 纯度 | ≥85% estimated by SDS-PAGE |
| 稳定性 | ≥ 1 year |
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