| 货号 | 2852/50 |
| 别名 | 6-(4-Methoxy-3-tricyclo[3.3.1.13,7] |
| 供应商 | Tocris |
| 生物活性 | Retinoic acid analog that is a RARβ and RARγ agonist (AC50 values are 2.2, 9.3, 22 and > 1000 nM for RARβ, RARγ, RARα and RXRα receptors respectively). Inhibits proliferation and induces apoptosis in colorectal cancer cell in vitro. Displays comedolytic activity. |
| 运输条件 | Blue Ice |
| 存放说明 | 4℃ |
| 纯度 | >98 % |
| 计算分子量 | 412.52 |
| 分子式 | C28H28O3 |
| 可溶性/溶解性 | Soluble to 25 mM in DMSO |
| CAS号 | 106685-40-9 |
| 参考文献 | Ockeret al (2003) The synthetic retinoid adapalene inhibits proliferation and induces apoptosis in colorectal cancer cells in vitro. Int.J.Cancer 107 453. PMID: 14506747. Millikan (2000) Adapalene: an update on newer comparative studies between the various retinoids. Int.J.Dermatol. 39 784. PMID: 11095202. Shrootet al (1997) Pharmacology and chemistry of adapalene. J.Am.Acad.Dermatol. 36 S96. PMID: 9204085. |