| 货号 | 14198-1mg |
| 描述 | 10Z-Hymenialdisine is a natural marine sponge alkaloid with numerous cellular actions. Most notably, it blocks signaling through the Raf-1/MEK-1/MAPK pathway by potently inhibiting MEK-1 (IC50 = 9 nM).1 Hymenialdisine also inhibits numerous kinases in vitro, most notably GSK3β, CDK1/cyclin B, CDK5/p25, CK1, and CDK2/cyclin E (IC50s = 10, 22, 28, 35, and 40 nM, respectively), as well as, less potently, ERK1/2 and several isoforms of PKC.2,3 Early studies demonstrated that it suppresses inflammatory gene expression by blocking signaling through NF-κB at micromolar concentrations.4 At similar concentrations, hymenialdisine also blocks bacterial quorum sensing.5 |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Tasdemir, D.,Mallon, R.,Greenstein, M., et al. Aldisine alkaloids from the Philippine sponge Stylissa massa are potent inhibitors of mitogen-activated protein kinase kinase-1 (MEK-1). Journal of Medicinal Chemistry 45(2), 529-532 (2002). 2.Meijer, L.,Thunnissen, A.M.W.H.,White, A.W., et al. Inhibition of cyclin-dependent kinases, GSK-3β and CK1 by hymenialdisine, a marine sponge constituent. Chemistry & Biology 7(1), 51-63 (2000). 3.Curman, D.,Cinel, B.,Williams, D.E., et al. Inhibition of the G2 DNA damage checkpoint and of protein kinases Chk1 and Chk2 by the marine sponge alkaloid debromohymenialdisine. The Journal of Biological Chemisty 276(21), 17914-17919 (2001). 4.Breton, J.J. and Chabot-Fletcher, M.C. The natural product hymenialdisine inhibits interleukin-8 production in U937 cells by inhibition of nuclear factor-κB. Journal of Pharmacology and Experimental Therapeutics 282(1), 459-466 (1997). 5.Dobretsov, S.,Teplitski, M.,Bayer, M., et al. Inhibition of marine biofouling by bacterial quorum sensing inhibitors. Biofouling 27(8), 893-905 (2011). | |
| 运输条件 | Wet ice in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥97% |
| 计算分子量 | 324.1 |
| 分子式 | C11H10BrN5O2 |
| CAS号 | 82005-12-7 |
| 稳定性 | ≥ 2 years |
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