| 货号 | 21044-10mg |
| 描述 | CVT-313 is a competitive inhibitor of cyclin-dependent kinase 2 (Cdk2; IC50 = 0.5 µM in vitro).1 It displays 8.5- and 430-fold selectivity for Cdk2 over Cdk1 and Cdk4, respectively, and has no effect on other unrelated ATP-dependent serine/threonine kinases.1 CVT-313 induces cell cycle arrest at the G1/S boundary.1 CVT-313 is often used as a selective Cdk2 inhibitor, although at some concentrations and in some cells it may also inhibit Cdk1.1,2,3,4 |
| 别名 | Cdk2 Inhibitor III; |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Brooks, E.E.,Gray, N.S.,Joly, A.H., et al. CVT-313, a specific and potent inhibitor of CDK2 that prevents neointimal proliferation. J. Biol. Chem. 272(46), 29207-29211 (1997). 2.Bhattacharjee, R.N.,Banks, G.C.,Trotter, K.W., et al. Histone H1 phosphorylation by Cdk2 selectively modulates mouse mammary tumor virus transcription through chromatin remodeling. Mol. Cell. Biol. 21(16), 5417-5454 (2001). 3.Dong, P.P.,Maddali, M.V.,Srimani, J.K., et al. Division of labour between Myc and G1 cyclins in cell cycle commitment and pace control. Nat. Commun. 5, 4750 (2014). 4.Senderowicz, A.M. and Sausville, E.A. Preclinical and clinical development of cyclin-dependent kinase modulators. Journal of the National Cancer Institute 92(5), 376-387 (2000). | |
| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 400.5 |
| 分子式 | C20H28N6O3 |
| CAS号 | 199986-75-9 |
| 稳定性 | ≥ 2 years |
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