Metastin (45-54)
货号：
20905-5mg 基本售价：
5250.0 元 规格：
5 mg
产品信息
概述| 货号 | 20905-5mg |
| 描述 | Metastin (45-54) is a 10 amino acid peptide that corresponds to the bioactive C-terminal 45-54 amino acids of metastin, a metastasis suppressor gene product.1 It acts as a potent agonist of GPR54 (OT7T175, AXOR12), with approximately 8-fold higher binding affinity than metastin (Ki values of 0.042 and 0.34 nM, respectively, for displacement of metastin (40-54)).1 Metastin (45-54) induces calcium mobilization in GPR54-transfected cells (EC50 = 0.18-1.1 nM).2 It inhibits the migration of GPR54-transfected CHO cells at concentrations of 10-100 nM, equaling the potency of full length metastin.3 |
| 别名 | Kisspeptin 10 (human); |
性能| 供应商 | Cayman |
| 应用文献 |
1.Ohtaki, T.,Shintani, Y.,Honda, S., et al. Metastasis suppressor gene KiSS-1 encodes peptide ligand of a G-protein-coupled receptor. Nature 411(6837), 613-617 (2001).
2.Tomita, K.,Niida, A.,Osishi, S., et al. Structure-activity relationship study on small peptidic GPR54 agonists. Bioor. Med. Chem. Lett. 14(22), 7595-7603 (2006).
3.Hori, A.,Honda, S.,Asada, M., et al. Metastin suppresses the motility and growth of CHO cells transfected with its receptor. Biochem. Biophys. Res. Commun. 286(5), 958-963 (2001).
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| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 1302.5 |
| 分子式 | C63H83N17O14 |
| CAS号 | 374675-21-5 |
| 稳定性 | ≥ 2 years |
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