NCOR2/SMRT (human recombinant)
货号：
11633-50ug 基本售价：
5250.0 元 规格：
50 ug
产品信息
概述| 货号 | 11633-50ug |
| 描述 | Nuclear receptor corepressor 2 (NcoR2) is a transcriptional corepressor that plays an essential role in the regulation of development and metabolism. Histone deacetylases (HDACs) can mediate nuclear receptor functions by forming co-repressor complexes with nuclear receptors in the absence of ligands. However, HDACs are primarily responsible for catalyzing the deacetylation of core histones. HDAC3, a class I HDAC related to the yeast HDAC Rpd, is inactive alone and requires binding with the deacetylase activation domain (DAD) of NcoR2 for activation.1 The deacetylation of core histones by HDACs results in the tightening of nucleosomal integrity, restriction of access to transcription factors, and the suppression of gene transcription. In addition, HDACs mediate other transcription regulatory pathways by associating with transcription factors, such as E2F, TFIIE, TFIIF, NF-κB, p300, Stat3, p53, and the retinoblastoma (Rb) protein.2 The modification of chromatin structure and other non-histone proteins by HDACs serves to control many complex biological events, including cell development, differentiation, programmed cell death, angiogenesis, and inflammation. Thus, dysregulation of HDACs, leading to an imbalance of acetylation and deacetylation, may be involved in the pathogenesis of various diseases, including cancer and inflammatory diseases.1 |
| 别名 | CTG Repeat Protein 26;Nuclear Receptor Corepressor 2;Silencing Mediator of Retinoic Acid and Thyroid Hormone Receptor;SMAP270;SMRT;T3 Receptor-Associating Factor;Thyroid-Retinoic-Acid-Receptor-Associated Corepressor;TRAC; |
性能| 供应商 | Cayman |
| 应用文献 |
1.Huang, L. Targeting histone deacetylases for the treatment of cancer and inflammatory diseases. Journal of Cellular Physiology 39.1, 611-616 (2006).
2.Lin, H.Y.,Chen, C.S.,Lin, S.P., et al. Targeting histone deacetylase in cancer therapy. Medicinal Research Reviews 26(4), 397-413 (2006).
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| 运输条件 | Dry ice in continental US; may vary elsewhere |
| 存放说明 | -80 |
| 稳定性 | ≥ 6 months |
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