| 货号 | 11211-50mg |
| 描述 | Sulfosuccinimidyl oleate (SSO) is an irreversible inhibitor of the fatty acid translocase CD36, blocking uptake of oleate, linoleate, or stearate by about 65% when added at 200 µM to adipocytes.1,2 It reduces the uptake of palmitate by mouse insulinoma MIN6 cells, preventing palmitate-induced changes in insulin secretion.3 SSO impairs saturated fatty acid-induced lipid accumulation and inflammation in RAW 264.7 macrophages.4 |
| 别名 | SSO; |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Harmon, C.M.,Luce, P.,Beth, A.H., et al. Labeling of adipocyte membranes by sulfo-N-succinimidyl derivatives of long-chain fatty acids: Inhibition of fatty acid transport. J.Membrane Biol. 121, 261-268 (1991). 2.Abumrad, N.A.,el-Maghrabi, M.R.,Amri, E.Z., et al. Cloning of a rat adipocyte membrane protein implicated in binding or transport of long-chain fatty acids that is induced during preadipocyte differentiation. Homology with human CD36. The Journal of Biological Chemisty 268(24), 17665-17668 (1993). 3.Noushmehr, H.,DAmico, E.,Farilla, L., et al. Fatty acid translocase (FAT/CD36) is localized on insulin-containing granules in human pancreatic β-cells and mediates fatty acid effects on insulin secretion. Diabetes 54(2), 472-481 (2005). 4.Nicholls, H.T.,Kowalski, G.,Kennedy, D.J., et al. Hematopoietic cell-restricted deletion of CD36 reduces high-fat diet-induced macrophage infiltration and improves insulin signaling in adipose tissue. Diabetes 60(4), 1100-1110 (2011). | |
| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥95% |
| 计算分子量 | 482.6 |
| 分子式 | C22H36NO7S • Na |
| 稳定性 | ≥ 2 years |
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