| 货号 | 19667-1ea |
| 描述 | This mixture contains a collection of vasoactive eicosanoids, including the characteristic metabolites of both prostaglandin I2(PGI2; Item No. 18220) and thromboxane A2(TXA2), as well as several additional HETE and EET metabolites produced by platelets and the cytochrome P450 pathway of arachidonic acid metabolism. The mixture is supplied in an amber ampule in which the headspace has been purged with argon to prevent lipid oxidation. This product has been designed for direct use in LC-MS applications. The solution may be serially diluted for preparation of calibrators and QC standards and/or used directly as a system suitability standard or tuning standard. After opening, we recommend that the mixture be transferred immediately to a 1 ml glass screw cap vial, to prevent solvent evaporation, and stored at -20°C. The mixture should be discarded after multiple freeze/thaw cycles. Whereas PGI2 is a potent vasodilator and inhibitor of human platelet aggregation, TXA2 causes irreversible platelet aggregation and contraction of vascular and bronchial smooth muscle. Because both are rapidly hydrolyzed and metabolized, TXB2 (Item No. 19030), 11-dehydro TXB2 (Item No. 19500), and 6-keto PGF1α (Item No. 15210) serve as useful markers for their synthesis.1,2 Certain HETEs and EETs have been shown to either inhibit platelet activation or regulate vasoconstriction.3,4,5,6,7,8,9 |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Ciabattoni, G.,Pugliese, F.,Davi, G., et al. Fractional conversion of thromboxane B2 to urinary 11-dehydrothromboxane B2 in man. Biochimica et Biophysica Acta 992, 66-70 (1989). 2.Brash, A.R.,Jackson, E.K.,Saggese, C.A., et al. Metabolic disposition of prostacyclin in humans. Journal of Pharmacology and Experimental Therapeutics 226, 78-87 (1983). 3.Hamberg, M., and Samuelsson, B. Prostaglandin endoperoxides. Novel transformations of arachidonic acid in human platelets. Proceedings of the National Academy of Sciences of the United States of America 71, 3400-3404 (1974). 4.Diczfalusy, U.,Falardeau, P., and Hammarström, S. Conversion of prostaglandin endoperoxides to C17-hydroxy acids catalyzed by human platelet thromboxane synthase. FEBS Letters 84, 271-274 (1977). 5.Ikei, K.N.,Yeung, J.,Apopa, P.L., et al. Investigations of human platelet-type 12-lipoxygenase: Role of lipoxygenase products in platelet activation. Journal of Lipid Research 53(12), 2546-2559 (2012). 6.McGiff, J.C., and Quilley, J. 20-HETE and the kidney: Resolution of old problems and new beginnings. American Journal of Physiology 277, R607-R623 (1999). 7.Katoh, T.,Takahashi, K.,Capdevila, J., et al. Glomerular stereospecific synthesis and hemodynamic actions of 8,9-epoxyeicosatrienoic acid in rat kidney. American Journal of Physiology 261, F578-F586 (1991). 8.Graber, M.N.,Alfonso, A., and Gill, D.L. Recovery of Ca2+ pools and growth in Ca2+ pool-depleted cells is mediated by specific epoxyeicosatrienoic acids derived from arachidonic acid. The Journal of Biological Chemisty 272, 29546-29553 (1997). 9.Catella, F.,Lawson, J.A.,Fitzgerald, D.J., et al. Endogenous biosynthesis of arachidonic acid epoxides in humans: Increased formation in pregnancy-induced hypertension. Proceedings of the National Academy of Sciences of the United States of America 87, 5893-5897 (1990). | |
| 运输条件 | Wet ice in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 稳定性 | ≥ 1 year |
| 本官网所有报价均为常温或者蓝冰运输价格，如有产品需要干冰运输，需另外加收干冰运输费。 |