| 货号 | 3356/50 |
| 别名 | 2-[(3-Aminopropyl)amino]ethanethiol |
| 供应商 | Tocris |
| 生物活性 | Cell-permeable reactive oxygen species scavenger that activates p53 through a JNK-dependent signaling pathway. Activates p21waf-1 and MDM2, represses transcription of Myc and thymidine kinase, and inhibits DNA topoisomerase IIα. Induces cell cycle arrest and exhibits cytoprotective activity towards normal cells but not cancer cells in vivo. Also exhibits broad spectrum antiviral activity in vitro. |
| 运输条件 | Blue Ice |
| 存放说明 | -20℃ |
| 计算分子量 | 207.16 |
| 分子式 | C5H14N2S.2HCl |
| 可溶性/溶解性 | Soluble to 100 mM in water and to 100 mM in DMSO |
| CAS号 | 14653-77-1 |
| 参考文献 | Walkeret al (2009) WR1065 mitigates AZT-ddl-induced mutagenesis and inhibits viral replication. Enviorn.Mol.Mutagen. 50460. Pluquetet al (2003) The cytoprotective aminothiol WR1065 activates p53 through a non-genotoxic signaling pathway involving c-Jun N-terminal kinase. J.Biol.Chem. 278 11879. PMID: 12531896. Northet al (2000) The cytoprotective aminothiol WR1065 activates p21waf-1 and down regulates cell cycle progression through a p53-dependent pathway. Oncogene 19 1206. PMID: 10713709. |