| 货号 | 3895/50 |
| 别名 | 6,7-Dichloro-1H-indole-2,3-dione 3-oxime |
| 供应商 | Tocris |
| 生物活性 | Positive modulator of small- and intermediate- conductance Ca2+-activated K+ channels (KCa2 and KCa3.1 channels); increases Ca2+ sensitivity. Displays no activity at BK channels. |
| 运输条件 | Blue Ice |
| 存放说明 | 4℃ |
| 纯度 | >98 % |
| 计算分子量 | 231.04 |
| 分子式 | C8H4Cl2N2O2 |
| 可溶性/溶解性 | Soluble to 100 mM in DMSO |
| CAS号 | 18711-16-5 |
| 参考文献 | Grgicet al (2009) Endothelial Ca2+-activated K+ channels in normal and impaired EDHF-dilator responses - relevance to cardiovascular pathologies and drug discovery. Br.J.Pharmacol. 157 509. PMID: 19302590. Morimuraet al (2006) Voltage-dependent Ca2+-channel block by openers of intermediate and small conductance Ca2+-activated K+ channels in urinary bladder smooth muscle cells. J.Pharm.Sci. 100237. Strobaeket al (2004) Activation of human IK and SK Ca2+-activated K+ channels by NS309 (6,7-dichloro-1H-indole-2,3-dione 3-oxime). Biochim.Biophys.Acta 1665 1. PMID: 15471565. |