| 货号 | 1368/1 |
| 别名 | 9,13-Dihydroxy-8,14,19-trimethoxy-4 |
| 供应商 | Tocris |
| 生物活性 | Selectively inhibits heat shock protein 90 (Hsp90). Binds to the ATP site of Hsp90 (Kd = 1.2 μM) and inhibits its chaperone activity. Consequently inhibits activities of oncogenic kinases (e.g. src, Raf), p53 and steroid receptors. Demonstrates antiproliferative effect on breast cancer stem-like cells. |
| 运输条件 | Blue Ice |
| 存放说明 | -20℃ |
| 纯度 | >98 % |
| 计算分子量 | 560.64 |
| 分子式 | C29H40N2O9 |
| 可溶性/溶解性 | Soluble to 10 mM in DMSO |
| CAS号 | 30562-34-6 |
| 参考文献 | Leeet al (2012) Inhibition of heat shock protein (Hsp) 27 potentiates the suppressive effect of Hsp90 inhibitors in targeting breast cancer stem-like cells. Biochimie. 94 1382. PMID: 22445681. Roeet al (1999) Structural basis for inhibition of the Hsp90 molecular chaperone by the antitumor antibiotics radicicol and geldanomycin. J.Med.Chem. 42 260. PMID: 9925731. Cardenaset al (1998) Signal-transduction cascades as targets for therapeutic intervention by natural products. Trends Biotechnol. 16 427. PMID: 9807840. Whitesellet al (1994) Inhibition of heat shock protein HSP90-pp60v-src heteroprotein complex formation by benzoquinone ansamycins: essential role for stress proteins in oncogenic transformation. Proc.Natl.Acad.Sci.U.S.A. 91 8324. PMID: 8078881. |