| 货号 | 0924/50 |
| 别名 | (5S,10R)-(+)-5-Methyl-10,11-dihydro |
| 供应商 | Tocris |
| 生物活性 | A potent, selective and non-competitive NMDA receptor antagonist. Acts by binding to a site located within the NMDA associated ion channel and thus prevents Ca2+ flux. An effective anti-ischemic agent in several animal models. Part of the Mixed NMDA Receptor Tocriset™. (-)-MK 801 maleate (Cat. No. 0955) also available. |
| 运输条件 | Blue Ice |
| 存放说明 | Ambient |
| 纯度 | >99 % |
| 计算分子量 | 337.37 |
| 分子式 | C16H15N.C4H4O4 |
| 可溶性/溶解性 | Soluble to 25 mM in water and to 100 mM in DMSO |
| CAS号 | 77086-22-7 |
| 参考文献 | Zajaczkowskiet al (1997) Uncompetitive NMDA receptor antagonists attenuate NMDA-induced impairment of passive avoidance learning and LTP. Neuropharmacology 36 961. PMID: 9257940. Hatfieldet al (1992) The dose-response relationship and therapeutic window for dizocilpine (MK-801) in a rat focal ischaemia model. Eur.J.Pharmacol. 216 1. PMID: 1526248. Gillet al (1991) The neuroprotective action of dizocilpine (MK-801) in the rat middle cerebral artery occlusion model of focal ischaemia. Br.J.Pharmacol. 103 2030. PMID: 1912992. Wonget al (1986) The anticonvulsant MK 801 is a potent N-methyl-D-aspartate antagonist. Proc.Natl.Acad.Sci.U.S.A. 83 7104. PMID: 3529096. |