| 货号 | 18443-5mg |
| 描述 | The cytochalasins are cell-permeable fungal metabolites that inhibit actin polymerization.1,2,3,4 This interferes with such diverse processes as cell movement, growth, phagocytosis, degranulation, and secretion.5,6,7,8 Cytochalasin J is a deacetylated analog of cytochalasin H that weakly inhibits actin assembly but significantly alters mitotic spindle microtubule organization and kinetochore structure.9,10 Like cytochalasin H, cytochalasin J suppresses the production of reactive oxygen species by stimulated human neutrophils.11 |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Brenner, S.L., and Korn, E.D. The effects of cytochalasins on actin polymerization and actin ATPase provide insights into the mechanism of polymerization. The Journal of Biological Chemisty 255(3), 841-844 (1980). 2.Lin, D.C.,Tobin, K.D.,Grumet, M., et al. Cytochalasins inhibit nuclei-induced actin polymerization by blocking filament elongation. Journal of Cell Biology 84, 455-460 (1980). 3.Ostlund, R.E., Jr.,Leung, J.T., and Hajek, S.V. Regulation of microtubule assembly in cultured fibroblasts. Journal of Cell Biology 85, 386-391 (1980). 4.Pinder, J.C., and Gratzer, W.B. Structural and dynamic states of actin in the erythrocyte. Journal of Cell Biology 96(3), 768-775 (1983). 5.Flaumenhaft, R.,Dilks, J.R.,Rozenvayn, N., et al. The actin cytoskeleton differentially regulates platelet α-granule and dense-granule secretion. Blood 105(10), 3879-3887 (2005). 6.Taheri-Talesh, N.,Horio, T.,Araujo-Bazán, L., et al. The tip growth apparatus of Aspergillus nidulans. Molecular Biology of the Cell 19, 1439-1449 (2008). 7.dos Santos, T.,Varela, J.,Lynch, I., et al. Effects of transport inhibitors on the cellular uptake of carboxylated polystyrene nanoparticles in different cell lines. PLoS One 6(9), 1-10 (2011). 8.Nightingale, T.D.,White, I.J.,Doyle, E.L., et al. Actomyosin II contractility expels von Willebrand factor from Weibel-Palade bodies during exocytosis. Journal of Cell Biology 194(4), 613-629 (2011). 9.Walling, E.A.,Krafft, G.A., and Ware, B.R. Actin assembly activity of cytochalasins and cytochalasin analogs assayed using fluorescence photobleaching recovery. Archives of Biochemistry and Biophysics 264(1), 321-332 (1988). 10.Wrench, G.A., and Snyder, J.A. Cytochalasin J treatment significantly alters mitotic spindle microtubule organization and kinetochore structure in PtK1 cells. Cell Motility and the Cytoskeleton 36(2), 112-124 (1997). 11.Chapla, V.M.,Zeraik, M.L.,Ximenes, V.F., et al. Bioactive secondary metabolites from Phomopsis sp., and endophytic fungus from Senna spectabilis. Molecules 19, 6597-6608 (2014). | |
| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥95% |
| 计算分子量 | 451.6 |
| 分子式 | C28H37NO4 |
| CAS号 | 53760-20-6 |
| 稳定性 | ≥ 2 years |
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