| 货号 | 18434-5mg |
| 描述 | The cytochalasins are cell-permeable fungal metabolites that inhibit actin polymerization.1,2,3,4 This interferes with such diverse processes as cell movement, growth, phagocytosis, degranulation, and secretion.5,6,7,8 Cytochalasin H is a potent inhibitor of actin incorporation into filaments.9,10 Like cytochalasin D (Item No. 11330), it also increases the steady-state diffusion coefficients of filaments, suggesting that it stimulates filament shortening.9 Cytochalasin H suppresses the production of reactive oxygen species by stimulated human neutrophils, blocks endocytosis of CD59 in lymphocytes, and shows anti-angiogenic activity both in vitroandin vivo.11,12,13 |
| 别名 | 17-Deoxo-21-acetylzygosporin D;Kodocytochalasin 1;Paspalin P1; |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Brenner, S.L., and Korn, E.D. The effects of cytochalasins on actin polymerization and actin ATPase provide insights into the mechanism of polymerization. The Journal of Biological Chemisty 255(3), 841-844 (1980). 2.Lin, D.C.,Tobin, K.D.,Grumet, M., et al. Cytochalasins inhibit nuclei-induced actin polymerization by blocking filament elongation. Journal of Cell Biology 84, 455-460 (1980). 3.Ostlund, R.E., Jr.,Leung, J.T., and Hajek, S.V. Regulation of microtubule assembly in cultured fibroblasts. Journal of Cell Biology 85, 386-391 (1980). 4.Pinder, J.C., and Gratzer, W.B. Structural and dynamic states of actin in the erythrocyte. Journal of Cell Biology 96(3), 768-775 (1983). 5.Flaumenhaft, R.,Dilks, J.R.,Rozenvayn, N., et al. The actin cytoskeleton differentially regulates platelet α-granule and dense-granule secretion. Blood 105(10), 3879-3887 (2005). 6.Taheri-Talesh, N.,Horio, T.,Araujo-Bazán, L., et al. The tip growth apparatus of Aspergillus nidulans. Molecular Biology of the Cell 19, 1439-1449 (2008). 7.dos Santos, T.,Varela, J.,Lynch, I., et al. Effects of transport inhibitors on the cellular uptake of carboxylated polystyrene nanoparticles in different cell lines. PLoS One 6(9), 1-10 (2011). 8.Nightingale, T.D.,White, I.J.,Doyle, E.L., et al. Actomyosin II contractility expels von Willebrand factor from Weibel-Palade bodies during exocytosis. Journal of Cell Biology 194(4), 613-629 (2011). 9.Walling, E.A.,Krafft, G.A., and Ware, B.R. Actin assembly activity of cytochalasins and cytochalasin analogs assayed using fluorescence photobleaching recovery. Archives of Biochemistry and Biophysics 264(1), 321-332 (1988). 10.Yahara, I.,Harada, F.,Sekita, S., et al. Correlation between effects of 24 different cytochalasins on cellular structures and cellular events and those on actin in vitro. Journal of Cell Biology 92, 69-78 (1982). 11.Chapla, V.M.,Zeraik, M.L.,Ximenes, V.F., et al. Bioactive secondary metabolites from Phomopsis sp., and endophytic fungus from Senna spectabilis. Molecules 19, 6597-6608 (2014). 12.Deckert, M.,Ticchioni, M., and Bernard, A. Endocytosis of GPI-anchored proteins in human lymphocytes: role of glycolipid-based domains, actin cytoskeleton, and protein kinases. J.CellBiol. 133(4), 791-799 (1996). 13.Lee, J.,Yi, J.M.,Kim, H., et al. Cytochalasin H, an active anti-angiogenic constituent of the ethanol extract of Gleditsia sinensis thorns. Biological and Pharmaceutical Bullentin 37(1), 6-12 (2014). | |
| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥95% |
| 计算分子量 | 493.6 |
| 分子式 | C30H39NO5 |
| CAS号 | 53760-19-3 |
| 稳定性 | ≥ 2 years |
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