Compound 56
货号：
17254-1mg 基本售价：
5194.0 元 规格：
1 mg
产品信息
概述| 货号 | 17254-1mg |
| 描述 | Compound 56 is a highly potent inhibitor of the tyrosine kinase activity of the epidermal growth factor receptor (EGFR; IC50 = 0.006 nM).1 It has been used to inhibit EGFR activity in pancreatic cancer cell lines and to induce the differentiation of rat mesenchymal stem cells.2,3 |
性能| 供应商 | Cayman |
| 应用文献 |
1.Bridges, A.J.,Zhou, H.,Cody, D.R., et al. Tyrosine kinase inhibitors. 8. An unusually steep structure-activity relationship for analogues of 4-(3-bromoanilino)-6,7-dimethoxyquinazoline (PD 153035), a potent inhibitor of the epidermal growth factor receptor. Journal of Medicinal Chemistry 39(1), 267-276 (1996).
2.Chandana, S.R.,Leece, C.M.,Gallo, K.A., et al. Inhibition of MLK3 decreases proliferation and increases antiproliferative activity of epidermal growth factor receptor (EGFR) inhibitor in pancreatic cancer cell lines. Cancer Growth Metastasis 3, 1-9 (2010).
3.Hwang, K.C.,Kim, J.Y.,Chang, W., et al. Chemicals that modulate stem cell differentiation. Proceedings of the National Academy of Sciences of the United States of America 105(21), 7467-7471 (2008).
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| 运输条件 | Wet ice in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥95% |
| 计算分子量 | 388.3 |
| 分子式 | C18H18BrN3O2 |
| CAS号 | 171745-13-4 |
| 稳定性 | ≥ 2 years |
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