| 货号 | 18442-1mg |
| 描述 | Cyclic ADP-ribose (cADP-ribose) is a calcium mobilizing nucleotide that is biosynthesized from NAD+ by cADP-ribose synthases, including CD38.1,2,3 cADP-Ribose appears to activate calcium channels in intracellular membranes, which in turn activate ryanodine receptors.3,4,5 8-bromo-cADP-Ribose is a stable, cell-permeable analog that blocks calcium release evoked by cADP-ribose in sea urchin egg homogenates with an IC50 value of 1.7 µM.6 It is commonly used to investigate intracellular signaling through cADP-ribose in isolated cells and tissues.7,8,9,10 |
| 别名 | 8-bromo-cADPR;8-bromo-cADP-Ribose; |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Lee, H.C.,Walseth, T.F.,Bratt, G.T., et al. Structural determination of a cyclic metabolite of NAD+ with intracellular Ca2+ -mobilizing activity. J. Biol. Chem. 264(3), 1608-1615 (1989). 2.Houtkooper, R.H.,Cantó, C.,Wanders, R.J., et al. The secret life of NAD+: An old metabolite controlling new metabolic signaling pathways. Endocr. Rev. 31(2), 194-223 (2010). 3.Guse, A.H. Biochemistry, biology, and pharmacology of cyclic adenosine diphosphoribose (cADPR). Curr. Med. Chem. 11, 847-855 (2004). 4.Lam, A.K.M. and Galione, A. The endoplasmic reticulum and junctional membrane communication during calcium signaling. Biochimica et Biophysica Acta 1833(11), 2542-2559 (2013). 5.Gerasimenko, O. and Gerasimenko, J. New aspects of nuclear calcium signalling. Journal of Cell Science 117(15), 3087-3094 (2004). 6.Lee, H.C. Mechanisms of calcium signaling by cyclic ADP-ribose and NAADP. Physiological Reviews 77(4), 1133-1164 (1997). 7.Bowden, S.E.H.,Selyanko, A.A. and Robbins, J. The role of ryanodine receptors in the cyclic ADP ribose modulation of the M-like current in rodent m1 muscarinic receptor-transformed NG108-15 cells. Journal of Physiology 519.1, 23-34 (1999). 8.Sanz, E.,Monge, L.,Fernandez, N., et al. Mechanisms of relaxation by urocortin in renal arteries from male and female rats. British Journal of Pharmacology 140, 1003-1007 (2003). 9.Durnin, L. and Mutafova-Yambolieva, V.N. Cyclic ADP-ribose requires CD38 to regulate the release of ATP in visceral smooth muscle. FEBS Journal 278, 3095-3108 (2011). 10.Park, D.R.,Shawl, A.I.,Ha, T.G., et al. Arginine thiazolidine carboxylate stimulates insulin secretion through production of Ca2+ - mobilizing second messengers NAADP and cADPR in pancreatic islets. PLoS One 10(8), e0134962 (2015). | |
| 运输条件 | Wet ice in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥95% |
| 计算分子量 | 620.2 |
| 分子式 | C15H20BrN5O13P2 |
| CAS号 | 151898-26-9 |
| 稳定性 | ≥ 2 years |
| 本官网所有报价均为常温或者蓝冰运输价格，如有产品需要干冰运输，需另外加收干冰运输费。 |