| 货号 | 10011361-100ug |
| 描述 | 14,15-Leukotriene D4(14,15-LTD4) is a member of an alternate class of LTs synthesized by a pathway involving the dual actions of 15- and 12-lipoxygenases (15- and 12-LOs) on arachidonic acid via 15-HpETE and 14,15-LTA4intermediates.1,2,3,414,15-LTD4 is classified as an eoxin (EXD4), because it is formed mostly by eosinophils.3 However, mast cells and nasal polyps can synthesize 14,15-LTD4 as well. Little is known about the physiological actions of 14,15-LTD4. It has weak contractile activity on both guinea pig ileum and pulmonary parenchyma in contrast to the effects of 5-LO-derived LTs.5,6 However, in an in vitro permeability assay, 14,15-LTD4 can increase vascular permeability of human endothelial cell monolayers, with similar potency to that of 5-LO-derived LTs, resulting in plasma leakage, a hallmark of inflammation.3 |
| 别名 | Eoxin D4;EXD4;14,15-LTD4; |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Yokoyama, C.,Shinjo, F.,Yoshimoto, T., et al. Arachidonate 12-lipoxygenase purified from porcine leukocytes by immunoaffinity chromatography and its reactivity with hydroperoxyeicosatetraenoic acids. The Journal of Biological Chemisty 261, 16714-16721 (1986). 2.Bryant, R.W.,Schewe, T.,Rapoport, S.M., et al. Leukotriene formation by a purified reticulocyte lipoxygenase enzyme. Conversion of arachidonic acid and 15-hydroperoxyeicosatetraenoic acid to 14,15-leukotriene A4. The Journal of Biological Chemisty 260, 3548-3555 (1985). 3.Feltenmark, S.,Gautam, N.,Brunnström, Å., et al. Eoxins are proinflammatory arachidonic acid metabolites produced via the 15-lipoxygenase-1 pathway in human eosinophils and mast cells. Proceedings of the National Academy of Sciences of the United States of America 105(2), 680-685 (2008). 4.Sailesh, S.,Kumar, Y.V.K.,Prasad, M., et al. Sheep uterus dual lipoxygenase in the synthesis of 14,15-leukotrienes. Archives of Biochemistry and Biophysics 315(2), 362-368 (1994). 5.Drazen, J.M.,Lewis, R.A.,Austen, K.F., et al. Contractile activities of structural analogs of leukotrienes C and D: Necessity of a hydrophobic region. Proceedings of the National Academy of Sciences of the United States of America 78(5), 3195-3198 (1987). 6.Sala, A.,Civelli, M.,Oliva, D., et al. Contractile and binding activities of structural analogues of LTC4 in the longitudinal muscle of guinea-pig ileum. Eicosanoids 3, 105-110 (1990). | |
| 运输条件 | Dry ice in continental US; may vary elsewhere |
| 存放说明 | -80 |
| 纯度 | ≥97% |
| 计算分子量 | 496.7 |
| 分子式 | C25H40N2O6S |
| CAS号 | 75290-64-1 |
| 稳定性 | ≥ 1 year |
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