| 货号 | 4536/50 |
| 别名 | 1-[4-Amino-2-(ethoxymethyl)-1H-imid |
| 供应商 | Tocris |
| 生物活性 | Toll-like receptor 7 (TLR7) agonist. Induces upregulation of IL-6, IL-12, IFN-γ and iNOS expression in mouse bone marrow-derived macrophages (BMMs). Inhibits RANKL-induced osteoclast differentiation in mouse BMMs and human peripheral blood monocytes. Also promotes the differentiation of MDSCs into macrophages and dendritic cells. Proinflammatory and antiviral. |
| 运输条件 | Blue Ice |
| 存放说明 | 4℃ |
| 纯度 | >98 % |
| 计算分子量 | 314.38 |
| 分子式 | C17H22N4O2 |
| 可溶性/溶解性 | Soluble to 100 mM in DMSO and to 50 mM in ethanol |
| 参考文献 | Leeet al (2014) Resiquimod, a TLR7/8 agonist, promotes differentiation of myeloid-derived suppressor cells into macrophages and dendritic cells. Arch.Pharm.Res. 37 1234. PMID: 24748512. Miyamotoet al (2012) R848, a toll-like receptor 7 agonist, inhibits osteoclast differentiation but not survival or bone-resorbing function of mature osteoclasts. Cytotechnology. 64 331. PMID: 22358541. Dockrell and Kinghorn (2001) Imiquimod and resiquimod as novel immunomodulators. J.Antimicrob.Chemother. 48 751. PMID: 11733457. Wagneret al (1999) Modulation of TH1 and Th2 cytokine production with the immune response modifiers, R-848 and imiquimod. Cell Immunol. 191 10. PMID: 9918682. |