| 货号 | 1261/50 |
| 别名 | erythro-9-(2-Hydroxy-3-nonyl)adenin |
| 供应商 | Tocris |
| 生物活性 | Selective inhibitor of cGMP-stimulated phosphodiesterase (PDE2) (IC50 = 0.8 - 4 mM). Also a potent inhibitor of adenosine deaminase. Suppresses spontaneous differentiation of human ESCs in feeder-free conditions. Also prevents directed neuronal differentiation. |
| 运输条件 | Blue Ice |
| 存放说明 | Ambient |
| 纯度 | >98 % |
| 计算分子量 | 313.83 |
| 分子式 | C14H23N5O.HCl |
| 可溶性/溶解性 | Soluble to 100 mM in water and to 100 mM in ethanol and to 100 mM in DMSO |
| CAS号 | 51350-19-7 |
| 参考文献 | Michieet al (1996) Rapid regulation of PDE-2 and PDE-4 cyclic AMP phosphodiesterase activity following ligation of the T-cell antigen receptor on thymocytes: analysis using the selective inhibitors erythro-9-(2-hydroxy-3-nonyl)-adenine (EHNA) and rolipram. Cell.Signal. 8 97. PMID: 8730511. Podzuweitet al (1995) Isozyme selective inhibition of cGMP-stimulated cyclic nucleotide phosphodiesterases by erythro-9-(2-hydroxy-3-nonyl)adenine. Cell.Signal. 7 733. PMID: 8519602. Bessodeset al (1982) Effect of chirality in erythro-9-(2-hydroxy-3-nonyl) adenine (EHNA) on adenosine deaminase inhibition. Biochem.Pharmacol. 31 879. PMID: 7082355. |