| 货号 | 4330/1 |
| 别名 | 3-Amino-5-[[2-[(2-methoxyethyl)amin |
| 供应商 | Tocris |
| 生物活性 | Potent and selective TRPV1 antagonist. Blocks Ca2+ uptake by CHO cells expressing TRPV1 receptors (IC50 values are 0.6 and 0.8 nM for capsaicin (Cat. No. 0462) and acid-induced Ca2+ uptake, respectively). Exhibits >4000-fold selectivity for TRPV1 over other TRP channels. Blocks capsaicin-induced flinch response and causes hyperthermia in rats. Orally available and non-CNS penetrant. |
| 运输条件 | Blue Ice |
| 存放说明 | -20℃ |
| 纯度 | >97 % |
| 计算分子量 | 472.42 |
| 分子式 | C22H19F3N6 |
| 可溶性/溶解性 | Soluble to 50 mM in DMSO |
| 参考文献 | Tamayoet al (2008) Design and synthesis of peripherally restricted transient receptor potential vanilloid 1 (TRPV1) antagonists. J.Med.Chem. 51 2744. PMID: 18386885. Gavvaet al (2007) The vanilloid receptor TRPV1 is tonically activated in vivo and involved in body temperature regulation. J.Neurosci. 27 3366. PMID: 17392452. |