| 货号 | 5838/1 |
| 供应商 | Tocris |
| 生物活性 | GIP receptor antagonist (IC50 = 2.6μM). Inhibits GIP-stimulated insulin release from pancreatic βcellsin vitro. In ob/ob mice, blocks the effects of GIP on insulin release and plasma glucose levels. Also improves intraperitoneal glucose tolerance, insulin sensitivity, and glucose response to feeding in ob/obmice. |
| 运输条件 | Blue Ice |
| 存放说明 | -20℃ |
| 计算分子量 | 4971.62 |
| 分子式 | C225H342N62O |
| 可溶性/溶解性 | Soluble to 2 mg/ml in water |
| 序列号 | YAPGTFISDYSIAMDKIRQQDFVNWLLAQR |
| 参考文献 | Irwinet al (2007) Early administration of the glucose-dependent insulinotropic polypeptide receptor antagonist (Pro3)GIP prevents the development of diabetes and related metabolic abnormalities associated with genetically inherited obesity in ob/ob mice. Diabetologia 50 1532. PMID: 17486314. Gaultet al (2002) Characterization of the cellular and metabolic effects of a novel enzyme-resistant antagonist of glucose-dependent insulinotropic polypeptide. Biochem.Biophys.Res.Commun. 290 1420. PMID: 11820780. |